by Admin | May 20, 2020 | Adverse Events, Vaccine Failure, Vaccine Shedding (viral shedding), Vaccines
“Although rotavirus vaccines are known to be shed in stools, transmission of vaccine-derived virus to unvaccinated contacts resulting in symptomatic rotavirus gastroenteritis has not been reported to our knowledge. We document here the occurrence of vaccine-derived rotavirus (RotaTeq [Merck and Co, Whitehouse Station, NJ]) transmission from a vaccinated infant to an older, unvaccinated sibling, resulting in symptomatic rotavirus gastroenteritis that required emergency department care.”
Pediatrics 2010
by Admin | May 20, 2020 | Adverse Events, Autoimmune Diseases, Immune System, Vaccine Failure, Vaccine Shedding (viral shedding), Vaccines
“Stool rotavirus testing was positive in all cases and the virus was identified as the vaccine strain in six cases. Prolonged viral shedding was documented in five cases.”
Vaccine 2010
by Admin | May 20, 2020 | Adverse Events, Vaccine Failure, Vaccine Shedding (viral shedding), Vaccines
“ A review of rotavirus vaccine prelicensure studies shows that viral shedding and transmission were higher with the old tetravalent rhesus rotavirus vaccine than with the current human attenuated monovalent rotavirus vaccine and the pentavalent bovine-human reassortant vaccine.”
The Lancet Infectious Diseases 2008
by Admin | May 20, 2020 | Vaccine Failure, Vaccine Shedding (viral shedding), Vaccines
“ Although nearly half of these reassortant-associated cases had underlying medical conditions, such as severe combined immunodeficiency disorder, further study is needed to understand the relationship between shedding, viral reassortants and underlying medical conditions.”
Expert Review Vaccines 2012
by Admin | May 20, 2020 | Vaccine Failure, Vaccine Shedding (viral shedding), Vaccines
“CONCLUSIONS: The findings of this study demonstrate that premature infants have positive stools by EIA, viral culture, and RT-PCR at varying time points during 2 weeks following first-dose immunization with RV5. RT-PCR shedding rates need to be clinically evaluated in the context of virus quantification by cell culture, which was low. No symptomatic transmission to HHC {household contacts} was detected in this study, supporting low transmissibility of vaccine virus shed by these infants born prematurely.”
Vaccine 2011
