Polysorbate 80-coated PLGA Nanoparticles Improve the Permeability of Acetylpuerarin and Enhance Its Brain-Protective Effects in Rats

“The study aimed to prepare polysorbate 80-coated poly(lactic-co-glycolic acid) (PLGA) nanoparticles to improve the permeability of AP across the blood-brain barrier (BBB) and enhance its brain-protective effects.

Conclusion: Polysorbate 80-coated PLGA-NPs can improve the permeability of AP cross the BBB and enhance its brain-protective effects in rats.”

The Journal of Pharmacy and Pharmacology

A Novel Delivery System of Cyclovirobuxine D for Brain Targeting: Angiopep-Conjugated Polysorbate 80-Coated Liposomes via Intranasal Administration

“The blood-brain barrier (BBB) poses a challenge for the treatment of cerebrovascular diseases including cerebral ischemia-reperfusion injury, Parkinson’s syndrome, and cerebral tumors. It was also reported that Polysorbate 80 (Tween 80, T80) plays a special role in brain targeting.”

Journal of Biomedical Nanotechnology

Multitargeted Nanoparticles Deliver Synergistic Drugs Across the Blood-Brain Barrier to Brain Metastases of Triple Negative Breast Cancer Cells and Tumor-Associated Macrophages

“Patients with brain metastases of triple negative breast cancer (TNBC) have a poor prognosis owing to the lack of targeted therapies, the aggressive nature of TNBC, and the presence of the blood-brain barrier (BBB) that blocks penetration of most drugs. In vitro and in vivo studies demonstrate that covalently bound polysorbate 80 in the terpolymer enables the low-density lipoprotein receptor-mediated BBB crossing and TAM-targetability of the TPLN. Conjugation of cyclic internalizing peptide (iRGD) enhances cellular uptake, cytotoxicity, and drug delivery to brain metastases of integrin-overexpressing TNBC cells.”

Advanced Healthcare Materials

Localized Delivery of Curcumin Into Brain With Polysorbate 80-modified Cerasomes by Ultrasound-Targeted Microbubble Destruction for Improved Parkinson’s Disease Therapy

“Treatment for Parkinson’s disease (PD) is challenged by the presence of the blood-brain barrier (BBB) that significantly limits the effective drug concentration in a patient’s brain for therapeutic response throughout various stages of PD. Herein, this paper fabricated curcumin-loaded polysorbate 80-modified cerasome (CPC) nanoparticles (NPs) with a mean diameter of ~110 nm for enhancing the localized curcumin delivery into the targeted brain nuclei via effective BBB opening in combination with ultrasound-targeted microbubble destruction (UTMD).”


Effect of Polysorbate 80 on the Intranasal Absorption and Brain Distribution of Tetramethylpyrazine Phosphate in Rats

“Drug delivery to the brain is limited by the blood-brain barrier (BBB). Intranasal delivery is a non-invasive route of drug administration which can bypass the BBB and contributed to a direct and rapid transport of drugs to the brain. Upon intranasal administration, the addition of polysorbate 80 significantly increased TMPP concentration in both plasma and brain linearly up to polysorbate 80 concentration 2%.”

Drug Delivery and Translational Research

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