Tuberculosis in Newborns: The Lessons of the “Lübeck Disaster” (1929-1933). Fox GJ, et al. PLoS Pathog. 2016.

“In an accident later known as the Lübeck disaster, 251 neonates were orally given three doses of the new Bacille Calmette-Guérin (BCG) antituberculosis (TB) vaccine contaminated with Mycobacterium tuberculosis. A total of 173 infants developed clinical or radiological signs of TB but survived the infection, while 72 died from TB.” 

PLoS Pathogens 2016

Specific T cell frequency and cytokine expression profile do not correlate with protection against tuberculosis after bacillus Calmette-Guérin vaccination of newborns

“CONCLUSIONS: The frequency and cytokine profile of mycobacteria-specific T cells did not correlate with protection against TB {tuberculosis}. Critical components of immunity against Mycobacterium tuberculosis, such as CD4 T cell IFN-γ production, may not necessarily translate into immune correlates of protection against TB disease.”

American Journal of Respiratory and Critical Care Medicine 2010 

A Pneumonia Case Associated with Type 2 Polio Vaccine Strains

“A 3-month-old male infant with no underlying diseases was admitted to Beijing Haidian Hospital on July 31, 2015, where he was diagnosed with lobular pneumonia exactly 26 days after he had received his second dose of trivalent OPV (tOPV). The infant was born from a second regular pregnancy by normal delivery (35/36 weeks gestation, birth weight: 3550 g). The infant also received two birth dose vaccinations (the Bacillus Calmette–Guerin vaccine and hepatitis B vaccine), and no adverse reactions to the vaccinations were reported. The infant had no signs of immunodeficiency. His family had no history of travel in the months before he became ill.” 

Chinese Medical Journal 2017

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