Increased Risk of Noninfluenza Respiratory Virus Infections Associated With Receipt of Inactivated Influenza Vaccine

We randomized 115 children to trivalent inactivated influenza vaccine (TIV) or placebo. Over the following 9 months, TIV recipients had an increased risk of virologically-confirmed non-influenza infections (relative risk: 4.40; 95% confidence interval: 1.31-14.8). Being protected against influenza, TIV recipients may lack temporary non-specific immunity that protected against other respiratory viruses.

Among the 115 participants who were followed up, the median duration of follow-up was 272 days (interquartile range, 264–285 days), with no statistically significant differences in age, sex, household size, or duration of follow-up between TIV and placebo recipients (Table 1). We identified 134 ARI episodes, of which 49 met the more stringent FARI case definition. Illnesses occurred throughout the study period (Supplementary Appendix Figure 1). There was no statistically significant difference in the risk of ARI or FARI between participants who received TIV and those who received placebo, either during winter or summer 2009 (Table 2).

Clinical Infectious Diseases

Low Vitamin D Status Occurs in 90% of Patients with ARDS and Is Associated with Longer Duration of Mechanical Ventilation

“Conclusion: Low vitamin D status was highly prevalent and almost universal in this cohort of patients with ARDS (90%). Although this high prevalence limited power for comparing outcomes, the presence of vitamin D deficiency was associated with fewer days free of mechanical ventilation independent of the severity of illness. Further study of the role of vitamin D in the prevention and treatment of ARDS is warranted.”

American Journal of Respiratory and Critical Care Medicine, 2016

Vaccine-related adverse events in Cuban children, 1999-2008.

“The DTwP vaccine exhibited the highest rate of adverse events. Common minor events were: fever (17,538), reactions at injection site (4470) and systemic side effects (2422). Rare events (by WHO definition) reported were: persistent crying (2666), hypotonic-hyporesponsive episodes (3), encephalopathy (2) and febrile seizures (112). Severe events included: anaphylaxis (2), respiratory distress (1), multiple organ failure (1), sudden death (1), vaccine-associated paralytic poliomyelitis (2), toxic shock syndrome (3), and sepsis (1). The 10 deaths and 3 cases of disability were investigated by an expert commission, which concluded that 8 of the 13 severe events were vaccination-related.” 

MEDICC Review 2012

Specific T cell frequency and cytokine expression profile do not correlate with protection against tuberculosis after bacillus Calmette-Guérin vaccination of newborns

“CONCLUSIONS: The frequency and cytokine profile of mycobacteria-specific T cells did not correlate with protection against TB {tuberculosis}. Critical components of immunity against Mycobacterium tuberculosis, such as CD4 T cell IFN-γ production, may not necessarily translate into immune correlates of protection against TB disease.”

American Journal of Respiratory and Critical Care Medicine 2010 

Effects of diphtheria-tetanus-pertussis or tetanus vaccination on allergies and allergy-related respiratory symptoms among children and adolescents in the United States.

“The odds of having a history of asthma was twice as great among vaccinated subjects than among unvaccinated subjects. DTP or tetanus vaccination appears to increase the risk of allergies and related respiratory symptoms in children and adolescents.”

Journal of Manipulative and Physiological Therapeutics 2000

Delay in diphtheria, pertussis, tetanus vaccination is associated with a reduced risk of childhood asthma.

“Among 11,531 children who received at least 4 doses of DPT, the risk of asthma was reduced to ½ in children whose first dose of DPT was delayed by more than 2 months. The likelihood of asthma in children with delays in all 3 doses was 0.39 (95% CI, 0.18-0.86).” 

Allergy and Clinical Immunology 2007

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