A large vaccine-derived poliovirus outbreak on Madura Island–Indonesia, 2005

by | May 20, 2020 | Adverse Events, Paralysis, Polio Vaccines, Vaccine Failure, Vaccine Shedding (viral shedding), Vaccines

“Between June and October 2005, 45 laboratory-confirmed type 1 vaccine-derived poliovirus (VDPV) cases were identified on Madura Island in Indonesia. Genetic sequencing data on VDPV isolates were consistent with replication and circulation for up to approximately 2 years. Concurrent circulation with type 1 wild poliovirus (WPV) enabled comparisons of VDPV and WPV cases and found that clinical and epidemiological features of both were similar. Attack rates for VDPV were as high as those for WPV. Of 41 VDPV case patients with known vaccination status, 25 (61%) had received zero oral polio vaccine (OPV) doses.” 

The Journal of Infectious Diseases 2008

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