“Present analyses and numerous observational studies indicate that age-associated Vitamin D deficiency may contribute to the high mortality of older adults and the elderly. Immediate availability for targeted experimental and clinical interrogations of potential COVID-19 pandemic mitigation agents, namely Vitamin D and Quercetin, as well as of the highly selective (Ki, 600 pm) intrinsically-specific FURIN inhibitor (a1-antitrypsin Portland (a1-PDX), is considered an encouraging factor. Observations reported in this contribution are intended to facilitate follow-up targeted experimental studies and, if warranted, randomized clinical trials to identify and validate therapeutically-viable interventions to combat the COVID-19 pandemic. Specifically, gene expression profiles of Vitamin D and Quercetin activities and their established safety records as over-the-counter medicinal substances strongly argue that they may represent viable candidates for further considerations of their potential utility as COVID-19 pandemic mitigation agents. Significantly, the interventional randomized clinical trial entitled “Effect of Vitamin D Administration on Prevention and Treatment of Mild Forms of Suspected COVID-19” was listed on ClinicalTrials.gov website (https://www.clinicaltrials.gov/ct2/show/NCT04334005 ) with the starting date April 10 and completion date June 30, 2020.”
Brazil’s Sao Paulo Pushes For Mandatory COVID Vaccinations
In September, Brazil's wealthiest and most populous state Sao Paulo went into contract with Chinese vaccine developer Sinovac Biotech, with the expectations to receive 46 million doses of CoronaVac. CoronaVac has been in Phase 3 testing in the South American country...
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