A case of systemic lupus erythematosus (SLE) following Human papillomavirus (HPV) vaccination

“A 15-year-old young woman received the Human papillomavirus (HPV) vaccines. Following the second HPV vaccination, intermittent fever, myalgia, arthritis and malar rash developed, and she was admitted to our hospital. Laboratory studies showed positive results for antinuclear antibody, anti-dsDNA antibody and anti-Sm antibody. Systemic lupus erythematosus (SLE) was diagnosed according to the Systemic Lupus International Collaborative Clinics 2012. Magnetic resonance imaging showed abnormal hyperintense areas in the fascia, and en bloc biopsy showed fasciitis. Reportedly, SLE developed after HPV vaccinations in some patients. Most such patients have a past or family history of autoimmune disease and presented SLE symptoms after the second vaccination. We describe herein a patient in whom SLE developed in association with HPV vaccination.”

PubMed

A case-control study of quadrivalent human papillomavirus vaccine-associated autoimmune adverse events

“It was observed that cases with the SAAE outcomes of gastroenteritis (odds ratio (OR) = 4.6, 95% confidence interval (CI) = 1.3-18.5), arthritis (OR = 2.5, 95% CI = 1.4-4.3), systemic lupus erythematosus (OR = 5.3, 95% CI = 1.5-20.5), vasculitis (OR = 4, 95% CI = 1.01-16.4), alopecia (OR = 8.3, 95% CI = 4.5-15.9), or CNS conditions (OR = 1.8, 95% CI = 1.04-2.9) were significantly more likely than controls to have received HPV4 vaccine (median onset of SAAE symptoms from 6 to 55 days post-HPV4 vaccination).”

PubMed

Bivalent HPV vaccine safety depending on subtypes of juvenile idiopathic arthritis

“15-year-old JIA (juvenile idiopathic arthritis) patient who developed severe pain and walking disability after injection of the bivalent HPV vaccine. She had had presentations of intermittent buttock pain and lumbago 2 years before vaccination. A few days after the first dose, she had persistent pain with joint swelling, which spread to multiple sites after further doses of the vaccine. She was diagnosed with enthesitis type JIA, confirmed by power-Doppler ultrasonography, and had bone erosion at the entheses.”

British Medical Journal

Autoimmune/auto-inflammatory syndrome induced by adjuvants (ASIA) after quadrivalent human papillomavirus vaccination in Colombians: a call for personalised medicine

“This was a case study in which 3 patients with autoimmune/auto-inflammatory syndrome induced by adjuvants (ASIA) after quadrivalent human papillomavirus vaccination (HPV) were evaluated and described. Our results highlight the risk of developing ASIA after HPV vaccination and may serve to increase the awareness of such a complication.”

PubMed

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