Effect of Polysorbate 80 on the Intranasal Absorption and Brain Distribution of Tetramethylpyrazine Phosphate in Rats

“Drug delivery to the brain is limited by the blood-brain barrier (BBB). Intranasal delivery is a non-invasive route of drug administration which can bypass the BBB and contributed to a direct and rapid transport of drugs to the brain. Upon intranasal administration, the addition of polysorbate 80 significantly increased TMPP concentration in both plasma and brain linearly up to polysorbate 80 concentration 2%.”

Drug Delivery and Translational Research

Reproductive and Developmental Toxicity of Formaldehyde: A Systematic Review

“Meta-analysis showing that formaldehyde — a known carcinogen and and ingredient in most childhood vaccines — exposure causes reproductive and developmental harm, including spontaneous abortions in pregnancy at low doses. Most studies included are in animals that can have similar drug reactions as humans because human toxicity studies are not ethical.”

Mutation Research, 2011

Adverse events following immunization with vaccines containing adjuvants.

“Forty-three out of 120 patients with moderate or severe manifestations following immunization were hospitalized from 2008 to 2011. All patients fulfilled at least 2 major and 1 minor criteria suggested by Shoenfeld and Agmon-Levin for ASIA diagnosis. The most frequent clinical findings were pyrexia 68%, arthralgias 47%, cutaneous disorders 33%, muscle weakness 16% and myalgias 14%. Three patients had diagnosis of Guillain-Barre syndrome, one patient had Adult-Still’s disease 3 days after vaccination. A total of 76% of the events occurred in the first 3 days post-vaccination. Two patients with previous autoimmune disease showed severe adverse reactions with the reactivation of their illness. Minor local reactions were present in 49% of patients. Vaccines containing adjuvants may be associated with an increased risk of autoimmune/inflammatory adverse events following immunization.”

Immunologic Research, 2013

United States Vaccine Court Rules SIDS Caused by Vaccination

“In this case, I have concluded, after review of the evidence, that it is more likely than not that the vaccines played a substantial causal role in the death of J.B. without the effect of which he would not have died. The role of inflammatory cytokines as neuro-modulators in the infant medulla has been well described and is likely the reason for a significant number of SIDS deaths occurring in conjunction with mild infection. I have concluded that it is more likely than not that the vaccine-stimulated cytokines had the same effect in this vulnerable infant during sleep.”

United States Court of Federal Claims

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